Chris Chipot
Centre National de la Recherche Scientifique Research Director
Adjunct professor of physics, University of Illinois at Urbana-Champaign

Phone : +33-(0)3-72-74-50-75
E-mail : and

Biographical sketch
Chris Chipot received his PhD in Theoretical Chemistry in 1994 from the Henri Poincaré University, in France, conducting research on intermolecular potentials with a fellowship from the Roussel Uclaf Institute. Following a post-doctorate in the Department of Pharmaceutical Chemistry of the University of California in San Francisco, he became a National Research Council post-doctoral fellow at the NASA Ames Research Center. He joined the CNRS in 1996 at the University of Lorraine, where he worked on the modeling of the biological membranes by means of computer simulations, while developing original approaches for free-energy calculations and the exploration of rare events. His developments also extend to the accurate description of intermolecular interactions, including induction phenomena. He received his habilitation in 2000 and was promoted research director in 2006. Since 2012, he has been directing an Associate International Laboratory established between the CNRS and the University of Illinois at Urbana-Champaign. He has a joint appointment with the Department of Physics at the University of Illinois at Urbana-Champaign.

Research areas
Modeling of protein-membrane interaction, free-energy calculations in biological systems, and development of intermolecular interaction potentials.

Scientific production
208 publications in peer-reviewed journals. 14 book chapters. 1 book. 74 invited talks in international conferences. 37 lectures at international scientific events. 64 invited seminars. 6 public lectures.h-index 54, i10-index 175, 27,700 cumulated citations.

Selected publications
  1. Gumbart, J. C.; Roux, B.; Chipot, C. Efficient determination of protein-protein standard binding free energies from first principles. J. Chem. Theor. Comput. 2013, 9, 3789-3798.
  2. Comer, J.; Gumbart, J. C.; Hénin, J.; Lelièvre, T.; Pohorille, A.; Chipot, C. The adaptive biasing force method: Everything you always wanted to know, but were afraid to ask. J. Phys. Chem. B 2015, 119, 1129-1151.
  3. Gumbart, J. Chipot, C. ; Schulten, K. Free-energy cost for translocon-assisted insertion of membrane proteins. Proc. Natl. Acad. Sci. USA 2011, 108, 3596-3601.
  4. Pohorille, A.; Jarzynski, C.; Chipot, C. Good practices in free-energy calculations. J. Phys. Chem. B, 2010, 114, 10235-10253 .
  5. Phillips, J. C.; Hardy, D. J.; Maia, J. D. C.; Stone, J. E.; Ribeiro, J. V.; Bernardi, R. C.; Buch, R.; Fiorin, G.; Hénin, J.; Jiang, W.; McGreevy, R.; Melo, M. C. R.; Radak, B. K.; Skeel, R. D.; Singharoy, A.; Wang, Y.; Roux, B.; Aksimentiev, A.; Luthey-Schulten, Z.; Kalé, L. V.; Schulten, K.; Chipot, C.; Tajkhorshid, E. Scalable molecular dynamics on CPU and GPU architectures with NAMD. J. Chem. Phys. 2020, 153, 044130.

Recent publications

Structure, substrate binding and symmetry of the mitochondrial ADP/ATP carrier in its matrix-open state
Joel Jose Montalvo-Acosta; Edmund R.S. Kunji; Jonathan J. Ruprecht; Francois Dehez; Christophe Chipot;
Biophysical Journal (2021)
Accurate Description of Cation-π Interactions in Proteins with a Nonpolarizable Force Field at No Additional Cost
Han Liu; Haohao Fu; Xueguang Shao; Wensheng Cai; Christophe Chipot;
Journal of Chemical Theory and Computation (2020) 31 (10): 671-6407
Cryo-EM and MD infer water-mediated proton transport and autoinhibition mechanisms of V
Soung-Hun Roh; Mrinal Shekhar; Grigore Pintilie; Christophe Chipot; Stephan Wilkens; Abhishek Singharoy; Wah Chiu;
Science Advances (2020) 10 (41): 5276-