Chris Chipot  
Centre National de la Recherche Scientifique Research Director
Adjunct professor of physics, University of Illinois at Urbana-Champaign

Phone :     +33-(0)3-83-68-40-97
Fax :         +33-(0)3-83-68-40-97
E-mail : and

Biographical sketch
Chris Chipot received his PhD in Theoretical Chemistry in 1994 from the Henri Poincaré University, in France, conducting research on intermolecular potentials with a fellowship from the Roussel Uclaf Institute. Following a post-doctorate in the Department of Pharmaceutical Chemistry of the University of California in San Francisco, he became a National Research Council post-doctoral fellow at the NASA Ames Research Center. He joined the CNRS in 1996 at the University of Lorraine, where he worked on the modeling of the biological membranes by means of computer simulations, while developing original approaches for free-energy calculations and the exploration of rare events. His developments also extend to the accurate description of intermolecular interactions, including induction phenomena. He received his habilitation in 2000 and was promoted research director in 2006. Since 2012, he has been directing an Associate International Laboratory established between the CNRS and the University of Illinois at Urbana-Champaign. He has a joint appointment with the Department of Physics at the University of Illinois at Urbana-Champaign.

Research areas
Modeling of protein-membrane interaction, free-energy calculations in biological systems, and development of intermolecular interaction potentials.

Scientific production
180 publications in peer-reviewed journals. 13 book chapters. 1 book. 69 invited talks in international conferences. h-index 50, i10-index 145, 21,800 cumulated citations.

Selected publications
  1. Gumbart, J. C.; Roux, B.; Chipot, C. Efficient determination of protein-protein standard binding free energies from first principles. J. Chem. Theor. Comput., 2013, 9, 3789-3798.
  2. Chandler, D.; Penin, F.; Schulten, K.; Chipot, C. The p7 protein of Hepatitis C forms structurally plastic ion channels. PLoS Comput. Biol., 2012, 8, e1002702
  3. Gumbart, J. Chipot, C. ; Schulten, K. Free-energy cost for translocon-assisted insertion of membrane proteins. Proc. Natl. Acad. of Sciences, USA, 2011, 108, 3596-3601.
  4. Pohorille, A.; Jarzynski, C.; Chipot, C. Good practices in free-energy calculations. J. Phys. Chem. B, 2010, 114, 10235-10253 .
  5. Phillips, J. C.; Braun, R.; Wang, W.; Gumbart, J.; Tajkhorshid, E.; Villa, E.; Chipot, C.; Skeel, L.; Schulten, K., Scalable molecular dynamics with NAMD. J. Comput. Chem. 2005, 26, 1781-1802.

Recent publications

Charge Transfer and Chemo-Mechanical Coupling in Respiratory Complex I
Chitrak Gupta; Umesh Khaniya; Chun Kit Chan; Francois Dehez; Mrinal Shekhar; M. R. Gunner; Leonid Sazanov; Christophe Chipot; Abhishek Singharoy;
Journal of the American Chemical Society (2020) 142 (20): 9220-9230
Free-Energy Landscape of Stepwise, Directional Motion in Multiple Molecular Switches
Shuangli Du; Han Liu; Xueguang Shao; Christophe Chipot; Wensheng Cai;
The Journal of Physical Chemistry C (2020) 124 (11): 6448-6453
Structural Basis for Broad HIV-1 Neutralization by the MPER-Specific Human Broadly Neutralizing Antibody LN01
Dora Pinto; Craig Fenwick; Christophe Caillat; Chiara Silacci; Serafima Guseva; Francois Dehez; Christophe Chipot; Sonia Barbieri; Andrea Minola; David Jarrossay; Georgia D. Tomaras; Xiaoying Shen; Agostino Riva; Maciej Tarkowski; Olivier Schwartz; Timothee Bruel; Jeremy Dufloo; Michael S. Seaman; David C. Montefiori; Antonio Lanzavecchia; Davide Corti; Giuseppe Pantaleo; Winfried Weissenhorn;
Microbe (2019) 26 (5): 623-637.e8