Chris Chipot  
Centre National de la Recherche Scientifique Research Director
Adjunct professor of physics, University of Illinois at Urbana-Champaign

Phone :     +33-(0)3-83-68-40-97
Fax :         +33-(0)3-83-68-40-97
E-mail : and

Biographical sketch
Chris Chipot received his PhD in Theoretical Chemistry in 1994 from the Henri Poincaré University, in France, conducting research on intermolecular potentials with a fellowship from the Roussel Uclaf Institute. Following a post-doctorate in the Department of Pharmaceutical Chemistry of the University of California in San Francisco, he became a National Research Council post-doctoral fellow at the NASA Ames Research Center. He joined the CNRS in 1996 at the University of Lorraine, where he worked on the modeling of the biological membranes by means of computer simulations, while developing original approaches for free-energy calculations and the exploration of rare events. His developments also extend to the accurate description of intermolecular interactions, including induction phenomena. He received his habilitation in 2000 and was promoted research director in 2006. Since 2012, he has been directing an Associate International Laboratory established between the CNRS and the University of Illinois at Urbana-Champaign. He has a joint appointment with the Department of Physics at the University of Illinois at Urbana-Champaign.

Research areas
Modeling of protein-membrane interaction, free-energy calculations in biological systems, and development of intermolecular interaction potentials.

Scientific production
148 publications in peer-reviewed journals. 13 book chapters. 1 book. 58 invited talks in international conferences. h-index 46, i10-index 116, 17,200 cumulated citations.

Selected publications
  1. Gumbart, J. C.; Roux, B.; Chipot, C. Efficient determination of protein-protein standard binding free energies from first principles. J. Chem. Theor. Comput., 2013, 9, 3789-3798.
  2. Chandler, D.; Penin, F.; Schulten, K.; Chipot, C. The p7 protein of Hepatitis C forms structurally plastic ion channels. PLoS Comput. Biol., 2012, 8, e1002702
  3. Gumbart, J. Chipot, C. ; Schulten, K. Free-energy cost for translocon-assisted insertion of membrane proteins. Proc. Natl. Acad. of Sciences, USA, 2011, 108, 3596-3601.
  4. Pohorille, A.; Jarzynski, C.; Chipot, C. Good practices in free-energy calculations. J. Phys. Chem. B, 2010, 114, 10235-10253 .
  5. Phillips, J. C.; Braun, R.; Wang, W.; Gumbart, J.; Tajkhorshid, E.; Villa, E.; Chipot, C.; Skeel, L.; Schulten, K., Scalable molecular dynamics with NAMD. J. Comput. Chem. 2005, 26, 1781-1802.

Recent publications

The lubricating role of water in the shuttling of rotaxanes
Haohao Fu; Xueguang Shao; Christophe Chipot; Wensheng Cai;
Chem. Sci. (2017) 139 (7): 293-5094

The Extended Generalized Adaptive Biasing Force Algorithm for Multidimensional Free-Energy Calculations
Tanfeng Zhao; Haohao Fu; Tony Lelievre; Xueguang Shao; Christophe Chipot; Wensheng Cai;
Journal of Chemical Theory and Computation (2017) 13 (4): 1566-1576

Tribute to Klaus Schulten
Emad Tajkhorshid; Christophe Chipot;
The Journal of Physical Chemistry B (2017) 121 (15): 3203-3205